Mmd effects5/14/2023 ![]() ![]() Onset for DM2 ranges from the second to the seventh decade of life, often presenting with myotonia, weakness, or cataracts. The CTG repeat size is usually in the range of 50 to 150. Age at onset is between 20 and 70 years (typically onset occurs after age 40), and life expectancy is normal. The mild form of DM1 is characterized by mild weakness, myotonia, and cataracts. The CTG repeat size in adult onset is generally in the range of 50 to 1,000. Patients diagnosed with DM1 have multiple sets of DNA bases repeats in their genome (known as the CTG repeats). In these patients, average lifespan is reduced. The classic form of DM1 becomes symptomatic between the second and fourth decades of life.
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